Molecular Dynamics of a Multidrug-resistant HIV-1 Protease
https://www.youtube.com/watch?v=9UX79g_RN-s Molecular Dynamics of a multidrug-resistant HIV-1 protease containing 20 mutations - undergoes efficient polyprotein processing even in the presence of clinical protease inhibitors - greater than 3 orders of magnitude decreased affinity for PIs darunavir and saquinavir Results show the ff: o Flaps relatively closed o Movements - almost about to open up at certain points o Twisting and turning movements evident o Internal binding site shifts in size over time consistent with being the cause of ineffectiveness of the ligands o too wide a space in the active site causes ligands to unbind more readily o consistent with experimental results o Intersubunit /dimer interface contacts seem to also be “looser”, causing more internal movement
Tentang Saya
o Biomedical scientist / Assistant Professor, M.Sc. Biochemistry o Educator (Univ. of Maryland - UMUC) - taught US military personnel o Bioinformatics and machine learning o Data mining of large datasets in the biomedical field and in commercial settings o Multi-award-winning photographer o Scientific and medical writing; research and editing work for technical write-ups / thesis / dissertations o SPSS and R, Weka, Knime etc. - data mining, analysis, and visualization software o Drug design and molecular dynamics of drug-resistant proteins I will NOT: - write scientific articles for you to publish (no ghostwriting) - that is academic dishonesty. - do your homework for you - try to work it out and ask for corrections instead. - do your problem sets for you - see above. - write your thesis for you - it's your thesis and your reputation. I can help edit it but not write it all for you. - do anything else that is dishonest or illegal.
