Academic Writing

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Here's an example of my academic writing skills. Below is a published abstract. Base pair dynamics of non-Watson & Crick U•U pair: Implications in Myotonic Dystrophy Ananth Prakash, Costerwell Khyriem and N. Yathindra Abundant expansion of trinucleotide repeats is implicated in broad range of neurological diseases termed Trinucleotide Repeat Expansion Disorders (TREDs). The human Myotonic Dystrophy type 1 (DM1), a multisystemic disorder, is associated with the occurrence of large copies of trinucleotide CUG repeats in the dystrophia myotonica-protein kinase (DMPK) transcript. These assemble into RNA duplexes comprising the canonical Watson & Crick (WC) base pairs interspersed with non-Watson & Crick (nWC) U·U base pairs. Repeats comprising U·U base pairs sequester MBNL-1 protein and modulates its intended function of mRNA splicing leading to DM1. Although much is known about the etiology of DM1, not much is understood about the underlying structural role. We examine the mechanistic effects of U·U base pairs on RNA duplex using molecular dynamics simulations. Results indicate a dynamic behavior of U·U base pairs with different hydrogen bonding schemes, that not only dictate base pair stability but also influence global RNA structure with implications on protein recognition and binding. U·U base pairs, during the course of simulations, are observed with two and one hydrogen bonds with varying levels of stability.

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